GramJS

const { Api, TelegramClient } = require("telegram");
const { StringSession } = require("telegram/sessions");

const session = new StringSession(""); // You should put your string session here
const client = new TelegramClient(session, apiId, apiHash, {});

(async function run() {
  await client.connect(); // This assumes you have already authenticated with .start()

  const result = await client.invoke(
    new Api.stickers.SetStickerSetThumb({
      stickerset: new Api.InputStickerSetID({
        id: BigInt("-4156887774564"),
        accessHash: BigInt("-4156887774564"),
      }),
      thumb: new Api.InputDocument({
        id: BigInt("-4156887774564"),
        accessHash: BigInt("-4156887774564"),
        fileReference: Buffer.from("arbitrary data here"),
      }),
    })
  );
  console.log(result); // prints the result
})();

import { Api, TelegramClient } from "telegram";
import { StringSession } from "telegram/sessions";

const session = new StringSession(""); // You should put your string session here
const client = new TelegramClient(session, apiId, apiHash, {});

(async function run() {
  await client.connect(); // This assumes you have already authenticated with .start()

  const result: Api.messages.StickerSet = await client.invoke(
    new Api.stickers.SetStickerSetThumb({
      stickerset: new Api.InputStickerSetID({
        id: BigInt("-4156887774564"),
        accessHash: BigInt("-4156887774564"),
      }),
      thumb: new Api.InputDocument({
        id: BigInt("-4156887774564"),
        accessHash: BigInt("-4156887774564"),
        fileReference: Buffer.from("arbitrary data here"),
      }),
    })
  );
  console.log(result); // prints the result
})();